Interní Med. 2017; 19(5): 232-236 | DOI: 10.36290/int.2017.058

Inflammatory bowel disease as a risk factor for colorectal cancer

MUDr. Jana Koželuhová, Ph.D., MUDr. Karel Balihar, Ph.D., MUDr. Jan Kotyza, MUDr. Eva Janská, prof. MUDr. Martin Matějovič, Ph.D.
I. interní klinika, Fakultní nemocnice Plzeň, Lékařská fakulta v Plzni, Univerzita Karlova v Praze

Colorectal cancer (CRC) is a feared complication of inflammatory bowel disease (IBD), dominantly in ulcerative colitis. The cumulativeprobability of developing this malignancy in ulcerative colitis (UC) is significantly higher than in the general population, makingUC the third highest risk condition for CRC (1). Because CRC is such a concerning complication of chronic inflammatory boweldiseases, it necessary to know the most important risk factors for its development as well as strategies for reducing incidence ofthis malignancy. This review presents not only the risk factors that predispose IBD patients to develop CRC, but more importantly,explores the accepted strategies for reducing this serious complication.

Keywords: colorectal cancer, ulcerative colitis, Crohn‘s disease, chemoprevention

Received: September 13, 2018; Accepted: November 1, 2018; Published: December 1, 2017  Show citation

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Koželuhová J, Balihar K, Kotyza J, Janská E, Matějovič M. Inflammatory bowel disease as a risk factor for colorectal cancer. Interní Med. 2017;19(5):232-236. doi: 10.36290/int.2017.058.
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