Interní Med. 2018; 20(4): 202-206 | DOI: 10.36290/int.2018.034
Hepatitis B virus (HBV) infection remains a global public health problem with changing epidemiology due to several factors predominantlyvaccination policy and migration. Chronic hepatitis B means the duration of HBV infection for more than 6 months.It is a dynamic process reflecting the interaction between HBV replication and the host immune response and not all patientswith chronic HBV infection have chronic hepatitis B. All patients with chronic HBV infection are in increased risk of progression toliver cirrhosis and hepatocellular carcinoma. The long-term administration of potent nucleos(t)ide analogue with high barrier ofresistance (tenofovir, entecavir) represents the treatment of choice. Pegylated interferon-alpha can also be considered in mid tomoderate chronic hepatitis B patients.
Published: October 1, 2018 Show citation