Role pacienta v českém zdravotnictví

Václav Krása

Interní Med. 2006; 8(10): 419  

Sjögren‘s syndrome

MUDr. Hana Ciferská, doc. MUDr. Pavel Horák CSc, MUDr. Zuzana Heřmanová, MUDr. Marta Ordeltová, doc. MUDr. Josef Zadražil CSc

Interní Med. 2006; 8(10): 423-426  

Sjögren‘s syndrome (SS) is chronic, autoimmune and inflammatory disease with predominant affection of exocrine glands, but also extragrandular manifestations are common occurrence. There are two forms of SS primary and secondary. Secondary SS is connected to presence of other autoimmune disease (rheumatoid arthritis, systemic lupus erythematosus etc.) For this disease is typical production of specific auto antibodies anti-SS-A (anti-Ro) and anti-SS-B (anti-La) and lymphocytary infiltration of exocrine glands. The treatment of SS is mainly symptomatic in the patients without organ manifestation. If the organ manifestation is present, the immunosuppressive...

Merit of natriuretic peptides for diagnosis, prognosis, management and therapy of heart failure

Eva Goncalvesová

Interní Med. 2006; 8(10): 428-431  

Natriuretic peptides are a group of hormones with important regulatory roles in the cardiovascular system. During the past five years, determination of level of BNP or a part of its precursor, so-called N-terminal pro-BNP, has become widely spread in the diagnostics and management of heart failure. Recombinant BNP – nesiritide – has been increasingly used for treatment of acute decompensation of heart failure in the U. S. The paper deals with issues of physiology of natriuretic peptides and use of measurement of serum level of BNP in clinical practice, as well as experience with therapeutic use of BNP.

Interferon α in the treatment for advanced renal cell carcinoma

MUDr. Šárka Lukešová, MUDr. Otakar Kopecký CSc, MUDr. Josef Dvořák, MUDr. Zdeněk Špriňar, MUDr. Dagmar Hlávková

Interní Med. 2006; 8(10): 432-438  

Patients with locally advanced stages of renal cell carcinoma (RCC) are at high risk of both distant relapse and locoregional disease progression, even after radical nephrectomy. Renal cell carcinoma is refractory to both chemotherapy and radiotherapy. Immunotherapy with interferon alfa (IFN-α) alone or in combination with other drugs has been evaluated in clinical trials for efficacy. IFN monotherapy in patients with metastatic RCC provides a modest but significant prolongation of survival with manageable side effects. A subset of patients, in particular those with good performance status, lung-only disease and resected primaries, may benefit...

Delirium and arrHythmias

MUDr. Marie Berková Ph.D, MUDr. Zdeněk Berka

Interní Med. 2006; 8(10): 439-442  

Delirium is a serious functional central nervous system (CNS) disorder of an unspecific etiology. Factors precipitating the functional disorder of CNS can arise arrhythmias. On the other hand arrhythmias can influence the haemodynamic status of the patient and take part in the genesis of delirium, especially in old persons. Delirium can develop as a secondary unwelcome effect of the antiarrhythmic treatment. On the other hand some psychopharmacologic drugs used in the therapy of delirium can cause serious arrhythmias. Delirium is an independent predictor of patient’s mortality in intensive care unit.

The endocrine function of adipose tissue in the pathogenesis of insulin resistance

MUDr. Jan Polák, MUDr. Eva Klimčáková, Mgr. Michaela Kováčiková, Ing. Michaela Vítková Ph.D, MUDr. Magda Bajzová, MUDr. Jindřiška Hejnová, doc. MUDr. Vladimír Štich Ph.D

Interní Med. 2006; 8(10): 443-446  

Adipose tissue is seen as a potent endocrine organ secreting besides free fatty acids also a number of endocrine substances (adipokines) which significantly influence insulin sensitivity in skeletal muscle, liver and adipose tissue. Number of these products participate in the regulation of inflammatory response and are involved in the state of low-grade inflammation, a risk factor for a development of atherosclerosis and type 2. diabetes. Farmacological as well as non-farmacological manipulations of adipose tissue endocrine functions are a potent instrument of improving insulin resistance and more hypolipidemics and antidiabetics are going to be developed...

NORMALIZACE SÉROLOGICKÝCH NÁLEZŮ PO ÚČINNÉ ANTIBIOTERAPII CHLAMYDIOVÝCH INFEKCÍ

doc. MUDr. Petr Hejnar Ph.D, doc. MUDr. Milan Kolář PhD, Mgr. Eva Hejnarová

Interní Med. 2006; 8(10): 454-456  

Diferenciální diagnostika bolestí na hrudi

MUDr. Jan Bajorek

Interní Med. 2006; 8(10): 457-459  

Pooperační výsledky plastik mitrální chlopně u pacientů indikovaných ke kardiochirurgické operaci pro ischemickou mitrální regurgitaci 2.-3. stupně

MUDr. Petr Vymětal, doc. MUDr. Petr Němec CSc, MUDr. Vilém Bruk, MUDr. Martin Troubil, MUDr. Marian Benčat

Interní Med. 2006; 8(10): 460-461  

CEREBRÁLNÍ TOXOPLAsMÓZA U NEMOCNÉHO S CHRONICKOU MYELOIDNÍ LEUKÉMIÍ PO ALOGENNÍ NEPŘÍBUZENSKÉ TRANSPLANTACI KRVETVORNÝCH BUNĚK

Ladislav Slováček, prof. MUDr. Ladislav Jebavý CSc, MUDr. Brigita Slováčková Ph.D, MUDr. Jan M. Horáček Ph.D, MUDr. Jaroslav Cerman Ph.D, Pavel Žák, MUDr. Petr Prášil

Interní Med. 2006; 8(10): 462-465  

Pharmacotherapy in pregnancy

MUDr. Tomáš Binder CSc

Interní Med. 2006; 8(10): 447-450  

The article presents the review of specificity of drug administration in various stages in pregnancy. In farther part the article adjudicates the drugs from the viewpoint of their teratogenicity and maleficence during the fetal developmental period. The general recommendations for pharmacotherapy in women in fertile age and during pregnancy and the review of recommended drugs in most frequent diseases are adduced in the end of the article.

Osteoporosis and schizophrenia

MUDr. Ivan Tůma CSc

Interní Med. 2006; 8(10): 451-453  

Osteoporosis is a multifactorial disease. Untreated patients with schizophrenia are at risk due to the consequences of the disease related lifestyle factors (nutritional alteration, smoking, polydipsia, lack of physical activity). The etiology of the osteoporosis may be partly explained by the prolacting-raising effect of antipsychotic medication. Hyperprolactinemia itself does not lead to osteoporosis. Decrease of bone mineral density associated with schizophrenia may result from hypogonadism secondary to antipsychotic-induced hyperprolactinemia. The most common clinical signs of hypogonadism is dys/amenorrhea, and galactorrhea in female patients,...