Potřebují lékaři lékařskou etiku?

doc. MUDr. Jiří Šimek, CSc.

Interní Med. 2013; 15(1): 3  

Fenofibrate and its pharmaceutical formulations

MUDr.Jaromíra Gajdová, doc.MUDr.Karel Urbánek, Ph.D.

Interní Med. 2013; 15(1): 5-10  

Fenofibrate belongs to the 3rd generation of fibrates and are one of the drugs of choice in pharmacotherapy of dyslipidemia. A number of studies demonstrated a positive effect of fibrate therapy in the prevention of cardiovascular disease. Fenofibrate is used in patients with mixed dyslipidemia with low HDL-cholesterol and high triglycerides. The mechanizm of their effect is delivered by activation of lipoprotein lipase through expression of PPAR alpha receptors. The main problem with using fenofibrate is low solubility, which causes uneven absorption. Therefore, new pharmaceutical formulations have been developed, which increase the surface...

Viral gastroenteritis, therapy

MUDr.Jana Táborská, Ph.D.

Interní Med. 2013; 15(1): 11-14  

Diarrheal diseases caused by viral agents have severe course especially in infants and children less than 5 years of age. Viral gastroenteritis may be also the cause of local outbreaks in home care facilities for seniors. The most important complication of viral gastroenteritis is dehydration with different seriousness. The most common etiological agent is rotavirus and norovirus. The therapy is only symptomatic and prevention non-specific. Infants can be protected by vaccine given orally.

Osteoporosis in men

MUDr.Jiří Jenšovský, CSc.

Interní Med. 2013; 15(1): 15-18  

Osteoporosis in men is a condition with an ever-increasing incidence. In spite of numerous specific features of the male skeleton and its development throughout life, both the diagnostic and therapeutic criteria are derived from the approach to osteoporosis in women. Men with proximal femoral fracture have a very significantly worse prognosis than women in this clinical situation. In men, it is always necessary to very carefully search for possible secondary causes of the disease. In therapeutic terms, data and approval for the treatment of male osteoporosis are available for substantially fewer products than in the case of osteoporosis in...

Acute kidney injury in patient with ehrlichiosis

MUDr.Magdaléna Mokrejšová, MUDr.Jiří Žabka, CSc.

Interní Med. 2013; 15(1): 22-24  

Ehrlichiosis is an infectious disease transmitted by ticks. The name of infectious agent is Anaplasma (originally called Ehrlichia) phagocytophilum. It is the intracellular patogen with an affinity for granulocytes causing immune disorders. This case report documents the development of acute kidney injury in patient with chronic ehrlichiosis, that was reason of severe parainfectious injury of renal tubulointerstitium during sepsis due to infectious endocarditis and bronchopneumonia. Management of sepsis by antibiotic therapy and erradication of ehrlichiosis (doxycycline) was crucial. marker proteins.

Body weight reduction in an obese woman with prediabetes in a two-year treatment with liraglutide and metformin

doc.MUDr.Rudolf Chlup, CSc., Emília Ďurajková

Interní Med. 2013; 15(1): 25-27  

The case report illustrates beneficial effects of a two-year off-label treatment with liraglutide and metformin in an obese woman with treated hypertension and prediabetes. After several years of failed attempts to reduce excessive body mass (82 kg, BMI 36.4 kg/m2), body weight decreased by 14 kg with one-year treatment and stagnated at around 70 kg in the subsequent year. HbA1c before and after treatment was repeatedly within normal limits.

Myalgic Encephalomyelitis - Practical Application of the International Consensus Criteria (ICC)

Ing.Jarmila Rýdlová, Ph.D., MUDr.Jaromíra Fabiánová

Interní Med. 2013; 15(1): 28-30  

The paper presents symptomatological analysis of ME/CFS based on the International consensus criteria, which are applied to a particular case of a patient suffering from this disease for nine years. The acquired knowledge is useful for a timely identification of the disease, which is very problematic from both diagnostic and therapeutic aspects.

New trends in diagnosis and therapy of diabetic macular edema

doc.MUDr.Bohdana Kalvodová, CSc., MUDr.Jan Kalvoda, Ph.D.

Interní Med. 2013; 15(1): 19-21  

Diabetic macular edema is the most important complication of both types of diabetes mellitus and the most common cause of visual impairment in patients affected by diabetes mellitus. A diabetic macular edema is defined as a retinal thickening caused by accumulation of fluid and/or hard exudates involving or approaching the center of the macula. Risk factors for the occurrence and progression of diabetic macular edema are duration of diabetes, hyperglycemia and systematic hypertension and severity of diabetic retinopathy. In the review article pathogenesis, clinical definition, diagnosis and therapy of the diabetic macular edema are described.

Incontinence-absorption products

MUDr.Lukáš Horčička

Interní Med. 2013; 15(1): 31-33  

Absorption products are an integral part of the care of patients with incontinence. Their use along with appropriate treatment improves the quality of life of affected individuals. The attending physician should be acquainted with their supply and options of use.

Must the start of insulin treatment in type 2 diabetes patients be connected with increasing of their body weight?

prof. MUDr. Jindřiška Perušičová, DrSc.1, et al.2

Interní Med. 2013; 15(1): 38-42  

BACKGROUND AND AIMS: The primary objective of the extended study KILOS I (=KILOS II) was to evaluate the change in body weight and BMI during next 12 months on insulin detemir treatment and to compare it with the changes in body weight and BMI during the previous 12 months of detemir treatment following another basal insulin (NPH, glargin) treatment. The secondary objective of the study was to evaluate the changes in glycaemic control measured by HbA1c. MATERIALS AND METHODS: This study was a 17-sites, open, not controlled, observational. Data of 168 patients with type 2 diabetes from study KILOS I were collected. In extended study the basic...

Complications of the subcutaneous administration of fluids and possibilities of their solutiones

doc. MUDr.Miroslav Kala, CSc.

Interní Med. 2013; 15(1): 36-37  

Dehydrated patients in the hospice palliative care can be easy managed by the subcutaneous administration of fluids (hypodermoclysis). Author describes possible complications of this method. But hypodermoclysis can be put down as easy, safe and cost-effective.

Akutní a chronické cor pulmonale v EKG obraze

doc. MUDr. Čestmír Číhalík, CSc.

Interní Med. 2013; 15(1): 34-35