Interní Med. 2009; 11(4): 155-158

Significance of combinations of oral antidiabetics in type 2 diabetes treatment

doc. MUDr. Alena Šmahelová Ph.D

Klinika gerontologická a metabolická, FN Hradec Králové

Current options of type 2 diabetes pharmacotherapy are broad. Recent knowledge has had a major impact on the therapeutic regimen

and procedure and has proved that glycaemic compensation cannot be obtained without oral antidiabetics. Given the fact that oral

antidiabetics gradually lose efficacy as monotherapy, timely combinations of various types of antidiabetics at lower doses are required.

Other, almost invariably present disorders (arterial hypertension, dyslipidaemia, coagulation disorders) require complex pharmacological



treatment: In a number of patients, it is possible to use combinations of oral antidiabetics, which combine the effects of metphormin

and sulphonylurea or thiazolidindiones, increase patient compliance and thus treatment success.

Keywords: type 2 diabetes mellitus, metabolic syndrome, oral antidiabetics, fixed combinations of oral antidiabetics.

Published: June 1, 2009  Show citation