Interní Med. 2009; 11(5): 236-239

Factor influencing aging of the human organism: genes and life style

prof. MUDr. František Šťastný CSc
Fyziologický ústav AVČR, Praha

The paper informs about possibilities of present medicine, but also individual life style, to influence the length and quality of our life.

Keywords: longevity, mTOR gene, diseases related to aging, life style.

Published: June 1, 2009  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Šťastný F. Factor influencing aging of the human organism: genes and life style. Interní Med. 2009;11(5):236-239.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Blahosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Discovery Today 2007; 12: 218-224. Go to original source... Go to PubMed...
    2. Jagger C, Gillies C, Moscone F, Cambois E, Van Oyen H, Nusselder W, Robine JM; EHLEIS team. Inequalities in healthy life years in the 25 countries of the European Union in 2005: a gross-national meta-regression analysis. Lancet 2008; 372: 2124-2131. Go to original source... Go to PubMed...
    3. Jagger C, Matthews RJ, Matthews FE, Robinson T, Robine JM, MRC-CFASl. The burden of diseases on disability-free life expectancy in later life. J Gerontol A Biol Sci Med Sci 2007a; 62: 408-414. Go to original source... Go to PubMed...
    4. Jagger C, Matthews R, Matthews F, Spiers NA, Nickson J, Paykel ES, Huppert FA, Brayne C, MRCCFAS. Cohort differences in disease and disability in the young-old: findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS). BMC Public Health 2007b; 13: 156-163. Go to original source... Go to PubMed...
    5. Lubitz J, Cai L, Kramarow E, Lentzner H. Health, life expectancy, and health care spending among the elderly. N Engl J Med 2003; 349: 1048-1055. Go to original source... Go to PubMed...
    6. Šťastný F. Genetická podstata Alzheimerovy nemoci a možnost její predikce. Psychiatrie 2008; 12: 207-213.
    7. Christensen K, McGue M, Petersen I, Jeune B, Vsupel JW. Exceptional longevity does not result in excessive levels of disability. Proc Natl Acad Sci USA 2008; 105: 13274-13279. Go to original source... Go to PubMed...
    8. Olshansky SJ, Perry D, Miller RA, Hitler RN. Pursuing the longevity dividend: scientific goals for an aging world. Ann NY Acad Sci 2007; 1114: 11-13. Go to original source... Go to PubMed...
    9. Cournil A, Kirkwood TB. If you would live long, choose your parents well. Trends Genet 2001; 17: 233-235. Go to original source... Go to PubMed...
    10. Wullschleger S, Loewith R, Hall MN. TOR signalling in growth and metabolism. Cell 2006; 124: 471-484. Go to original source... Go to PubMed...
    11. Dann SG, Selvaraj A, Thomas G. mTOR complex 1-S6K1 signaling: at the crossroad of obesity, diabetes and cancer. Trends in Molec Med 2007; 13: 252-259. Go to original source... Go to PubMed...
    12. Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene 2006; 25: 6436-6446. Go to original source... Go to PubMed...
    13. Plas DR, Thomas G. Tubers and tumors: rapamycin therapy for benign and malignant tumors. Curr Opin Cell Biol 2009; 00: 000-000. Go to original source... Go to PubMed...
    14. Chen D, Guarente L. SIR2: a potential target for calorie restriction mimetics. Trends Molec Med 2007; 13: 64-71. Go to original source... Go to PubMed...
    15. Milne JC, Denu JM. The sirtuin family: therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 2008; 12: 11-17. Go to original source... Go to PubMed...
    16. Perušičová J. Metformin, inzulinová rezistence a kardiovaskulární riziko. Farmakoterapie 2006; 7: 55-60.
    17. Evans JMM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005; 330: 1304-1305. Go to original source... Go to PubMed...
    18. Staňková T. Terapie obezity. Edukafarm medinews 2007; 2: 77-78.
    19. Smékal V. Křesťanský životní styl. Universum 2008; 18: 24-27.
    20. Gatz M, Prescott CA, Pedersen NL. Lifestyle risk and delaying factors. Alzheimer Dis Assoc Disord 2006; 20: S84-S88. Go to original source... Go to PubMed...
    21. Batty GD, Shipley MJ, Gale CR, Mortensen LH, Deary IJ. Does IQ predicts total and cardiovascular disease mortality as strongly as other risk factors? Heart 2008; 94: 1541-1544. Go to original source... Go to PubMed...
    22. Deary I. Why do intelligent people live longer? Nature 2008; 456: 175-176. Go to original source... Go to PubMed...

    Return to the content


    Internal Medicine for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.