Interní Med. 2008; 10(7): 348-349
ENDOMICROSCOPY AND ITS APPLICATION IN EXAMINATIONS OF THE GASTROINTESTINAL TRACT
- II. interní klinika, Thomayerova nemocnice, Praha
Modern endoscopic techniques enable acquisitions of very accurate images of surfaces of the gastrointestinal mucosa down to very subtle details. These techniques nonetheless do not allow for displaying images of surfaces of the examined area in morphological detail. This is why in recent years we have seen advanced development of techniques of so-called endomicroscopy – including endoscopic cystoscopy and laser-scanning confocal endomicroscopy. Both endomicroscopic techniques enable in vivo images of the respective area during a concurrent routine endoscopic examination including observation of histological structures. These techniques could facilitate faster and more accurate diagnostics, they may possibly result in a decrease of biopsies and this technique can also be applied with patients where biopsy can not be executed.
Keywords: Key words: endoscopy, endoscopic cystoscopy, laser-scanning confocal endomicroscopy.
Published: October 1, 2008 Show citation
References
- Eberl T, Jechart G, Probst A, Golczyk M, Bittinger M, Scheubel R, Arnholdt H, Knuechel R, Messmann H. Can an endocytoscope system (ECS) predict histology in neoplastic lesions? Endoscopy 2007; 39: 497-501.
Go to original source... 
Go to PubMed... - Fuji T, Iishi H, Tatsuta M, Hirasawa R, Uedo N, Hifumi K, Ornori M. Effectiveness of premedication with pronase for improving visibility during gastroendoscopy: a randomized controlled trial. Gastrointest. Endosc 1998; 47: 382-387. Go to original source... Go to PubMed...
- Gotoh A, Akamatsu T, Shimizu T, Shimodaira K, Kaneko T, Kiyosawa K, Ishida K, Ikeno T, Sugiyama A, Kawakami Y, Ota H, Katsuyama T, Additive Effect of Pronase on the Efficacy of Eradication Therapy Against Helicobacer pylori, Helicobacter 2007, 3: 183-191. Go to original source... Go to PubMed...
- Chiu PWY, Inoue H, Satodate H, Kazawa T, Yoshida T, Sakashita M, Kudo SE. Validation of the quality of histological images obtained of fresh and formalin-fixed specimens of esophageal and gastric mucosa by laser-scanning confocal microscopy. Endoscopy 2006; 38: 236-240. Go to original source... Go to PubMed...
- Inoue H, Kudo S, Shiokawa A. Novel endoscopic imaging techniques toward in vivo observation of libiny cancer cells in the gastrointestinal tract. Dig. Dis 2004; 22: 334-337. Go to original source... Go to PubMed...
- Inoue H, Sasajima K, Kaga M, Sugaya S, Sato Y, Wada Y, Inui M, Satodate H, Kudo SE, Kimura S, Hamatani S, Shiokawa A. Endoscopic in vivo evaluation of tissue atypia in the esophagus using a newly designed integrated endocytoscope: a pilot trial. Endoscopy 2006; 38: 891-895. Go to original source... Go to PubMed...
- Kakeji Y, Yamaguchi S, Yoshida D, Tanoue K, Ueda M, Masunari A, Utsunomiya T, Imamura M, Honda H, Maehara Y, Hashizum M. Development and assessment of morphologic criteria for diagnosing gastric cancer using confocal endomicroscopy: an ex vivo and in vivo study. Endoscopy 2006; 38: 886-890. Go to original source... Go to PubMed...
- Kieslich R, Burg J, Vieth M, et al. Confocal laser endoscopy for diagnosig intraepitelial neoplasias and colorectal cancer in vivo. Gastroenterology 2004; 127: 706-713. Go to original source... Go to PubMed...
- Kumagai Y, Monma K, Kawada K. Magnifying chromoendoscopy of the esophagus: In vivo pathological diagnosis using an endocytoscopy system. Endoscopy 2004; 36: 590-594. Go to original source... Go to PubMed...
- Meroni E, Gatteschi B, Fasoli A, Munizzi F, Frascio F, Pugliese V, Truini M. Detection of tissue abnormalities in normal mucosa surrounding colorectal cancer using an endocytoscopy system. Endoscopy 2007; 39: 369-370. Go to original source... Go to PubMed...
- Saito N, Sato F, Oda A, Kato M, Takeda H, Sugiyama T, Asaka M. Removal of mucus for ultrastructural observation of the surface of human epithelium using pronase. Helicobacter 2002; 7: 112-115. Go to original source... Go to PubMed...
- Sakashita M, Inoue H, Kashida H, Tahala J, Cho JY, Satodate H, Hidaka E, Yoshida T, Fukami N, Tamagai Y, Shikawa A, Kudo S. Virtual histology of colorectal lesions using laser-scanning confocal microscopy. Endoscopy 2003; 35: 1033-1038. Go to original source... Go to PubMed...
- Sano Y, Saito Y, I Fu K, Matsuda T, Uraoka T, Kobayashi N, Machida H, Iwasaki J, Emura F, Hanafusa M, Yoshino T, Kato S, Fuji T. Efficacy of magnifying chromoendoscopy for the differential diagnosis of colorectal lesions. Digestive Endoscopy 2005; 17: 105-116. Go to original source...
- Sasajima K, Kudo S, Inoue H, Takeuchi T, Kashida H, Hidaka E, Kawachi H, Sakashita M, Tahala J, Shiokawa A. Real-time in vivo virtual histology of colorectal lesions when using the endocytoscopy system. Gastrointest. Endosc 2006; 63: 1010-1017. Go to original source... Go to PubMed...
- Zambelli A, Villanacci V, Buscarini E, Bassotti G, Confocal laser endromicroscopy assessment of coeliac disease: a preliminary report. Poster UEGW Paris October 2007.