Interní Med. 2006; 8(12): 519
Interní Med. 2006; 8(12): 523-525
In the time before a discovery of insulin diabetic decompensation (ketoacidosis or hyperosmolar syndrome) was the main cause of death of type 1 diabetics and one of the most frequent causes of death of type 2 diabetics. After discovery of insulin and potent sulfonyluea oral antidiabetics and their introduction into therapeutic practice, another quite frequent complication appeared – hypoglycaemia. A development of lactic acidosis may be a side effect of treatment with biguanids. Recently, clinical importance of acute complications stepped behind thanks mainly to patient’s education and blood sugar self-monitoring. Nevertheless should...
Interní Med. 2006; 8(12): 526-530
Sudeck dystrofia is more than 100 years cited name for a set of symptoms of complications of trauma or surgery, mostly in extremities. Subjective symptoms are dominated by unexplainable pain, usually distal to primary lesion, objectively we find local swelling and change of colour, local temperature and sweating. All this affects naturally the functionality of the concerned extremity. If the vitious circle – i. e. extermination of local hypoxia caused by vasomotor instability – is not broken, the status can within weeks to months progress to serious and irreversible trophical changes of skin and its adnexa, muscles and tendons, to...
Interní Med. 2006; 8(12): 531-533
The choice of the optimal heart valve for replacement depends above all on patients age. After that it is necessary to take into consideration patients concomitant diseases, his expected lifespan and his relation to anticoagulant therapy. Bioprostheses are recomended in patients over 65 years, but do not have risk factor of trombembolism and in patients with expected short lifespan and there are considered for right sided valves replacement too. Mechanical heart valves are implanted in remaining situations.
Interní Med. 2006; 8(12): 557-558
Interní Med. 2006; 8(12): 548-550
Interní Med. 2006; 8(12): 551-553
Interní Med. 2006; 8(12): 545-547
Atorvastatin belongs to the most important medications against cardiovascular diseases. The efficacy was proved on cardiovascular events and is mediated by its hypolipemic action. Its high doses (80 mg) were in the treatment of cardiovascular diseases safe and more effective than lower doses or medium doses of less potent statins. If the high dosage is more effective than medium doses of potent statins (40 mg atrovastatin and equivalent doses of other statins) is not clear. It is also not clear whether theses high doses are safe in combination with fibrates.
Interní Med. 2006; 8(12): 534-538
Antiaggregation treatment is safe and evidently efficient already during the acute phase of ischaemic stroke. Nevertheless, it is dominantly used in patients after stroke or transitory ischaemic event, for the secondary prevention of stroke recurrence. Antiaggregation is indicated in all stroke patients, except the subgroup, selected for long-term anticoagulation. Antiaggregation drugs with proved safety and efficacy are following: Acetylsalicylic acid (ASA), thienopyridines and dipyridamole. ASA is a basic antiaggregation drug. Its efficacy is not directly dose-dependent, with recommended dosage of 50–325 mg daily. In case of the clinical...
Interní Med. 2006; 8(12): 539-544
Interní Med. 2006; 8(12): 554-556