CO MOHOU PŘINÉST KLUBY PACIENTŮ?

Ing. Josef Mrázek, CSc.

Interní Med. 2010; 12(6): 299  

Non-steroidal antiphlogistics in gastroenterology

doc.MUDr.Zdena Zádorová, Ph.D.

Interní Med. 2010; 12(6): 302-305  

The large majority of peptic ulcerations that are not associated with H. pylori infection are associated with NSAID ingestion. Peptic ulceration with NSAIDs typically causes no symptoms, but NSAID – induced ulcers can be symptomatic and complicated by GI bleeding, perforation and/or obstruction. Asymptomatic ulcerations can be documented endoscopically in 15 % to 45 % of patients on chronic NSAID therapy.

Current position of betablockers in treatment of arterial hypertension

MUDr.Eduard Němeček, prof.MUDr.Aleš Linhart, DrSc.

Interní Med. 2010; 12(6): 306-307  

In cardiology betablockers have a big importance in secondary preventative indications. Their very important task is evidenced in treatment of patients who suffer from ischemic heart disease and also in treatment of heart failure of patients who suffer from systolic dysfunction. Although in most of recommendation they are presented like medicine of the first choice in arterial hypertension, evidence for their administration in this indication is not by far so strong. We can explain it by their negative impact on metabolism (overweight, negative affection of lipid profile, setback resistence to insulin, more frequent recurrence of diabetes)...

Familial combined hyperlipidemia

MUDr.David Karásek, Ph.D., prof.MUDr.Helena Vaverková, CSc., MUDr.Dagmar Jackuliaková, doc.MUDr.Zdeněk Fryšák, CSc., MUDr.Milan Halenka, Ph.D., MUDr.Dalibor Pastucha, Ph.D.

Interní Med. 2010; 12(6): 308-311  

Familial combined hyperlipidemia is the most common genetic hyperlipidemia with a high risk of early atherosclerosis manifestation. Authors of the review present current knowledge concerning to prevalence, etiology, pathogenesis, laboratory findings, diagnostic criteria, clinical manifestation and management of familial combined hyperlipidemia.

Fever as a single symptom in the patient suffered from fast evolving solid tumor

MUDr.Helena Trumpešová, MUDr.Martina Mišejková, MUDr.Hana Dujsíková, Ph.D., prof.MUDr.Jan Lata, CSc., MUDr.Leoš Křen, Ph.D.

Interní Med. 2010; 12(6): 325-326  

This case report describes a case of a young patient which has been widely investigated at the department of infectious diseases and at the department of hepatogastroenterology due to the fever and following hepatic damage of unknown origin. Despite of the use of several modern methods and interdisciplinary approach, the diagnosis of rare tumor came too late and with fatal consequences.

Effect of smoking on treatment with tiotropium

MUDr.Jana Kociánová

Interní Med. 2010; 12(6): 327-329  

The 4-year UPLIFT study provided a vast amount of data on COPD patients. The subsequent analysis addressed the effect of smoking habit in relation to the effect of treatment with tiotropium. The study results clearly indicate a therapeutic benefit for all COPD patients, regardless of the smoking habit and the reasons for treatment with tiotropium in smokers.

Chronic myeloid and chronic lymphocytic leukemia

doc.MUDr.Edgar Faber, CSc., MUDr.Renata Urbanová

Interní Med. 2010; 12(6): 321-324  

Incidence of chronic myeloid (CML) and B chronic lymphocytic leukemia (B-CLL) remain about the same but their prevalence has been steadily increasing due to the success of modern treatment in recent period. Diagnostics is based in both conditions upon the results of full blood count, immunophenotyping (in B-CLL and blastic phase of CML only) and cytogenetic examination that serves for confirmation of diagnosis of CML, however, in B-CLL is needed for actual risk assessment. Prognosis of patients with CML has been dramatically improved after introduction of imatinib and second generation tyrosine kinase inhibitors so hematopoietic stem cell transplantation...

Combined therapy of crural ulcers

MUDr.Lada Baručáková, MUDr.Yvetta Vantuchová, Ph.D.

Interní Med. 2010; 12(6): 312-315  

Crural ulcer is defined as a chronic wound that is located on the lower extremities. It affects about 1 % of the productive population and 4–5 % of the population above 70 years. It is a chronic disease reducing all aspects of life quality. This review deals with the ethiology and classification of wounds and is focused on the healing and therapy of crural ulcers.

Age related macular degeneration

doc.MUDr.Tomáš Sosna, CSc., MUDr.Magdalena Netuková, Ph.D., MUDr.Petra Sedláčková, MUDr.Radka Švancarová

Interní Med. 2010; 12(6): 316-320  

Age related macular degeneration is the most common cause of blindness in developed countries. It is assumed that its prevalence will incrementally grow with increasing age. The various forms of the disease, its incidence, prevalence, pathogenesis and risk factors leading to its development are described in this review article. In view of the difficulty for this treatment, prevention including adequate education and well-balanced nutrition which may prevent development of the disease are highlighted.

Acute diarrhoea

MUDr.Jan Galský, Ph.D.

Interní Med. 2010; 12(6): 336-338  

Worldwide, diarrhoeal diseases are second only to respiratory infections in frequency. Based on socioeconomic conditions and depending on community and personal hygiene, the yearly incidence is 3–5 episodes per one inhabitant. The most serious complication is dehydration resulting in renal failure and multiple organ dysfunction syndrome. Therefore, prompt and adequate rehydration is of major significance in the treatment of diarrhoeal disease.

Hepatitis C, diagnosis, treatment, prevention

MUDr.Adam Vitouš

Interní Med. 2010; 12(6): 339-342  

Chronic hepatitis C infection, affecting 3 % of the world’s population, is one of the major therapeutic and economic health burdens. Implementation of molecular genetic methods into clinical practice has improved diagnostic possibilities. Following the introduction of interferon alfa monotherapy at the end of the 20th century and, more recently, the current standard treatment protocol of pegylated interferon alfa plus ribavirin, individualized by patient’s viral load and genotype, the number of infected patients achieving sustained antiviral response has improved. However, a significant number of infected people are either not responding...

How to deal with insect stings and reaction to the allergen?

MUDr.Vojtěch Thon, Ph.D.

Interní Med. 2010; 12(6): 330-332  

Allergic reactions to insect stings can cause bright variety of symptoms from local extreme swelling to systemic anaphylaxis. Systemic reactions affect 3 % of adults and 1 % of children. Severe reactions can occur at any age without warning. The treatment of choice for acute anaphylaxis is epinephrine injection. Diagnostic tests should be carried out in all patients with a history of a systemic reaction to detect sensitization. Testing comprises skin test with Hymenoptera venoms and serologic evidence of venom-specific IgE antibodies. Hymenoptera venoms contain glycoprotein allergens which are unique to each family but are similar among the...

How to perform hand hygiene?

MUDr.Dana Hedlová

Interní Med. 2010; 12(6): 334-335  

There are a number of factors that can increase the risk of acquiring healthcare associated infections, but high standards of infection control practice minimise the risk of occurrence. In healthcare settings, hand hygiene can prevent potentially fatal infections from spreading from patient to patient and from patient to healthcare worker and vice-versa. Hand hygiene is one of the most cost-effective measures in control and prevention of infections.

Autodidaktický test 6/2010

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Interní Med. 2010; 12(6): 343