Prohru nad nemocí a stářím člověka je těžké přiznat

MUDr. Anna Křivancová

Interní Med. 2008; 10(11): 491  

Oral antidiabetic agents - treatment of type 2 diabetes

MUDr. Pavlína Piťhová

Interní Med. 2008; 10(11): 494-497  

Oral antidiabetic agents (OAD) are preparations used in Type 2 Diabetes mellitus treatment. There is important to manage both metabolic disorders in diabetic patients – impaired insulin sensitivity and dysfunction in insulin secretion as well. Basic tools in optimal metabolic control are preparations that influence mainly fasting glycemia (metformin, thiazolidindions) and mainly postprandial glycemia (acarbose, insulin secretagogues, incretin mimetics). Incretin mimetics work in more levels of glucose metabolism regulations and form a new quality in antidiabetic treatment. There is possible to combine various species of oral antidiabetic...

Novelties in antiretroviral therapy of HIV/AIDS infection

doc. MUDr. Marie Staňková CSc

Interní Med. 2008; 10(11): 498-501  

HIV infection remains an incurable disease because of the impossibility to eradicate the HIV from the organism. However, the combination antiretroviral therapy (cART) is able to efficiently limit HIV replication and slow down progression of immunodeficienci and thus prolog and improve the quality of HIV+ patients‘ lives. In HIV+ pregnant women, the antiretroviral therapy substantially reduces the risk of vertical transmission of infection. The development of new antiretroviral drugs is breathtaking and the speed with which the US Food and Drug Administration approves new drugs for clinical use is unprecedented. The development continues, extending...

Chronic obstructive pulmonary disease nowadays

MUDr. Pavel Turčáni

Interní Med. 2008; 10(11): 502-507  

The article briefly discusses complex therapy, which is currently available for patients with COPD. It is based on pharmacological and nonpharmacological strategies. The emphasis is placed on basic characteristics of individual modalities and practical use of the presented knowledge in everyday practice.

Erbitux a léčba karcinomu rekta

MUDr. Dagmar Brančíková

Interní Med. 2008; 10(11): 526-528  

Úspěšná léčba těžké otravy karbamazepinem opakovanou hemoperfuzí

MUDr. Soňa Štěpánková, et. al

Interní Med. 2008; 10(11): 529-530  

Pneumocystová pneumonie u HIV pozitivních osob

MUDr. Juraj Kultan

Interní Med. 2008; 10(11): 531-534  

Pharmacotherapy of diabetic retinopathy - idle wishes or reality?

doc. MUDr. Tomáš Sosna CSc

Interní Med. 2008; 10(11): 511-516  

Diabetic retinopathy (DR) is one of the most frequent causes of decrease of vision in developed countries. It is known that the most important is prevention that lays on optimal control of diabetes, but also other risk factors. Laser therapy, in spite of being „evidence based“, is a strategy essentially empiric and destructive and principles of therapy effects are not well understood. Pharmacotherapy of DR tries to be based on well known facts in pathophysiology and histopathology of the disease and to influence the process selectively. The article discusses individual groups of medications and their influence of diabetic retinopathy.

Effect of phytoestrogens on menopausal symptoms and breast cancer

prof. Ing. Jitka Moravcová CSc

Interní Med. 2008; 10(11): 517-519  

High intake of phytoestrogens in foods has been proposed to be responsible for the lower endocrine cancer risk in Asia in comparison to West countries. However, results of both epidemiologic and clinical studies are often controversial and nowadays there are no data to support the idea that isoflavone consumption improves the prognosis of breast cancer patients. The article summarizes current knowledge on the biologic effects and exposure levels of phytoestrogens in particular from the point of breast cancer risk and improvement of menopausal symptomps. The attention is also focused on the generally accepted recommendations concerning the daily intake...

Tension-type headache

doc. MUDr. Otakar Keller CSc

Interní Med. 2008; 10(11): 520-521  

Tension-type headache is the most common headache which affects almost all population at least ones in life. Episodic tension-type headache and chronic tension-type headache are disorders characterised by high frequency of attacs. In some cases is attended by contractions of pericranial muscles. It can be brought on physical and psychological stress and improper working positions. Abnormal neuronal sensitivities are proposed as another cause. The approach to the treatment of tension-type headache consists of physical, pharmaco- and psychotherapy. Specific care has to be given to prevent of drug overuse.

Scars

MUDr. Kateřina Klauzová

Interní Med. 2008; 10(11): 522-525  

Many articles have been published on improving the appearance of scar, however, there are no definitive management protocols. This article show possibilities of therapy for various types of scar.

Jak bojovat s únavou?

MUDr. Šárka Lukešová

Interní Med. 2008; 10(11): 536-538