Čeština v medicíně - chrám a tvrz, nebo důvod k pláči?

Mgr. Jaroslav Hořejší

Interní Med. 2010; 12(10): 463, 508  

Proton pumps inhibitors therapy prescribed by internists and cardiologist at outpatients clinic

prof.MUDr.Milan Lukáš, CSc., MUDr.Dana Ďuricová

Interní Med. 2010; 12(10): 466-469  

Introduction of proton pump inhibitors (PPIs) into clinical practice meant the significant advance in therapy of acido-peptic disorders. PPIs are the most important drugs for the therapy of gastro-esophageal reflux diseases, peptic ulcer disease, Helicobacter pylori infection eradication as well as they are the most powerful prophylactic therapy against NSAIDs gastropathy. PPIs are usually administered in one morning dose. The treatment with other secretolytic drugs, which increase the intragastric pH level simultaneously with PPIs are wholy inappopriate. The safety profil based on long-term experience, seems to be very safe. Currently, an...

Long term therapy of osteoporosis

MUDr.Martina Skácelová, doc.MUDr.Pavel Horák, CSc., MUDr.Martin Žurek, Ph.D.

Interní Med. 2010; 12(10): 470-478  

Osteoporosis is the most common metabolic bone disease which leads to an increased risk of fractures. Products used in therapy reduce bone resorption or stimulate bone formation. There are many unanswered questions in the treatment of osteoporosis regarding the efficacy and safety of long-term therapy, as well as an assessment of its effects or risks associated with the discontinuation of treatment. Bisphosphonates are potent inhibitors of the bone resorption, their prolonged use increases bone mineral density in the lumbar spine and hip and reduces the risk of osteoporotic fractures. Discontinuation of bisphosphonates increases the bone resorption...

Antiplatelet and anti-inflammatory effect of statins

MUDr.Zoltán Paluch, Ph.D., Mgr.Zlata Heřmánková

Interní Med. 2010; 12(10): 479-481  

The paper provides a short general introduction to and an overview of antiplatelet and anti-inflammatory effect of statins. The underlying pathophysiology, mechanism and significance for clinical practice are briefly mentioned. The areas that are still subject to intensive research are outlined.

Breakthrough pain and it’s treatment

MUDr.Pavlína Nosková

Interní Med. 2010; 12(10): 482-486  

Breakthrough pain (BP) is defined as transitory pain that occurs on a background of relatively well controlled baseline pain. This pain character can join pain of tumour disease origin but not only that one. Question to specify the character of pain should be common in daily contact with a patient. To resolve this problem it seems neccessary to provide patients wit rescue mediation with rapid 30 minute onset. The article comes with analgetics review according to WHO classificaton and suitable for BP and available in the Czech republic. From the point of fast onset view we are looking for new approaches and application routs practical also for...

Current perspective on indications for administering the combination of ACEI and sartans

prof.MUDr.Jiří Vítovec, CSc., FESC, prof.MUDr.Jindřich Špinar, CSc., FESC

Interní Med. 2010; 12(10): 487-489  

The article deals with the pathophysiological basis for the combination of angiotenzin-converting enzyme (ACE) inhibitors and angiotenzin II type 1 receptor blockers (sartans) in the treatment of hypertension, heart failure and conditions after myocardial infarction and in the secondary prevention of coronary artery disease. The risks of combining these substances are discussed, particularly in terms of recent critical literature reviews of this combination, and a very careful consideration of the indications for coadministration of ACE inhibitors and sartans is emphasised. myocardial infarction, coronary artery disease.

Lékaři řady odborností diskutovali o nových pohledech na chlamydiové infekce

MUDr. Drahomíra Polcarová

Interní Med. 2010; 12(10): 520-521  

The case report of the patient with diagnosis tropical ulcer

MUDr.Kateřina Radoušová

Interní Med. 2010; 12(10): 502-503  

The synonyms of ulcus tropicum are desert ulcer or tropical phagedena. It is ulcer almost caused by mixed bacterial infection (the most often streptococci and a variety of gramnegative organisms in culture), usually involving traumatic wounds of the legs, often in patients with malnutrition and with chronic diseases. It´s occur usually in warm, damp climates, primarily in adults. Epidemics may occur in military troops or plantation workers. Penicilin is most often used therapy because of its price and availability in poor regions. In case of allergy is possible to use cephalosporins, aminoglycosides or ciprofloxacin. Also important is care...

Intracranial bleeding associated with selective serotonin reuptake inhibitor paroxetine

prof.MUDr.Alexandra Žourková, CSc.

Interní Med. 2010; 12(10): 504-505  

and coadministration with ibuprofen The observational case report deal with a 48-year old woman who used paroxetine and ibuprofen developed intracranial bleeding. Paroxetine and ibuprofen synergistically inhibit platelet function. Doctors should be aware of the increased risk of hemorrhage among patients on selective serotonin reuptake inhibitors.

Cerebral venous trombosis covered by migraine

MUDr.Miroslava Fauknerová, MUDr.Tomáš Peisker, MUDr.Eva Medová, MUDr.David Doležil, Ph.D.

Interní Med. 2010; 12(10): 506-508  

A 26-year-old patient, currently on hormonal contraceptive medication, with a prior medical history of common migraine and a mild head injury was admitted in our department for typical presentation of a migrenous headache. No significant neurological findings during her medical examination. Due to the prolonged course of a headache, risk factors and changes in presentation of a headache a CT scan was requested. Due to the suspission of venous thrombosis MRI of the brain was also requested. Thrombosis of the sigmoid and transverse sinuses were proven. It is a tendency or common practise, not to pay so much attention as to include secondary cause...

Is metformin only an antidiabetic drug?

prof.MUDr.Jindřiška Perušičová, DrSc.

Interní Med. 2010; 12(10): 516-519  

For over fifty years, metformin has been known as an effective antihyperglycaemic drug not associated with weight gain. In recent years, it has been successfully used in nondiabetic situations as well. Metformin substitutes for the lack of safe anti-obesity medications, is the drug of choice in women with PCOS and is therapeutically valid in individuals with NASH. The most significant activity of metformin that has been shown recently is its anti-tumorous effect in a number of cancers.

Principles of patient preparation for blood collection and preanalytical phase of laboratory testing

prof.MUDr.Tomáš Zima, DrSc.

Interní Med. 2010; 12(10): 490-493  

Laboratory testing requires adequate patient instruction on the factors that may interfere with laboratory testing such as physical activity, diet, drink intake, medications, smoking, alcohol consumption, and others. Biological factors are modifiable (diet, physical exercise, and others) or non-modifiable (age, sex, biological rhythms). Most frequently, blood is collected after an overnight fast in the morning hours. The patient is required to fast for about 10–12 hours while, at the same time, being recommended to drink 2–3 dL of water in the morning. The so-called preanalytical phase of laboratory testing includes patient preparation,...

Headache and hormones

MUDr.Ingrid Niedermayerová

Interní Med. 2010; 12(10): 494-496  

Migraine is a typical disease with a significant influence of women sex hormones. In trigeminal autonomic cephalgias is activated hypothalamus during attacks. Migrainelike headache is the most common presentation of pituitary adenomas, clusterlike headache is less often. Pituitary apoplexy is manifested by thunderclap headache. Headache is presented in 30 % patient with hypothyroidism. Paroxysmal headache occur in 50–80 % patients with phaeochromocytoma. Migraines with aura in females is more likely to worsen due to combined oral hormonal contraception and are higher at risk of migraine stroke, especially with those who smoke. Administration...

Diagnostics and treatment of ENT infections

MUDr.Petra Bruthansová, doc.MUDr.Jan Plzák, Ph.D.

Interní Med. 2010; 12(10): 497-500  

Review of the most common upper airway and upper digestory tract infections: rhinitis acuta, sinusitis acuta, laryngitis acuta and tonsilitis is presented. The paper is focused on clinical course and possible complications. Therapy and diagnostic approach is proposed.

How to follow patients with oncology disease in a family?

MUDr.Lenka Foretová, Ph.D.

Interní Med. 2010; 12(10): 510-515  

Cancer diseases are mostly polyfactorial, but in 5–10 % of cases the disease may be of hereditary origin. Mutations in a high-risk gene are transmitted from generation to generation and increase the probability of cancer occurrence many times. Genetic examination should be indicated in families with repeated cancer, especially in young age, with multiple malignancies, with combination of rare cancers. In families where the disease is probably not hereditary, the prevention in relatives is also important, evaluation of the risk and offering a preventive care is important. This follow-up of relatives of cancer patients is not routinely done.

Autodidaktický test 8/2010

Interní Med. 2010; 12(10)