Jak je to s personalizovanou medicínou?

prof. MUDr. Vladimír Palička, CSc.

Interní Med. 2011; 13(11): 419  

The options of medicamentous therapy in Crohn´s disease and ulcerative colitis

prof.MUDr.Milan Lukáš, CSc.

Interní Med. 2011; 13(11): 422-426  

Aminosalicylates, corticosteroids, immunosuppressants, and recently also biological therapy are the mainstays of pharmacotherapy of inflammatory bowel diseases (IBD). Aminosalicylates (sulphasalazine, mesalazine) are essential drugs for both induction and maintenance treatments of patients with ulcerative colitis. They are administered orally, in limited disease they may also be administered locally in the form of suppositorias or enemas or rectal foams. Corticosteroids with systemic effect have a strong anti-inflammatory effect and are used in oral or parenteral therapy in patients with a severe course of Crohn´s disease and ulcerative colitis....

The reality of the compliance of the recommendation for nutrition in practice - nutrition like a prevention

doc.MUDr.Věra Adámková, CSc.

Interní Med. 2011; 13(11): 427-430  

of the civilization diseases Final dietary recommendations for the CR population, which issued January 20, 2009 Society for Nutrition, based on European recommendations, however, they are adapted to Czech real options (option exemplary higher intake of trans fatty acids). Recommendations maintain a favorable ratio of individual groups of nutrients, fats, sugars, protein, fiber and so on. If we follow the recommended quantity and composition of food we can substantially contribute to improving our health and reduce the risk of manifestation of the serious diseases, so called civilization diseases, which include not only cardio- cerebrovascular...

Warfarin therapy management - myths and facts

MUDr.Ondřej Moravec, MUDr.Martin Hutyra, Ph.D., MUDr.Tomáš Skála, Ph.D., doc.MUDr.Miloš Táborský, CSc., FESC, MBA

Interní Med. 2011; 13(11): 431-435  

Oral anticoagulant therapy has become a cornestone in many internal cases. As the population as a whole is aging, the number of patients who need warfarin is likewise increasing. The main problem of this therapy is due to the difficulty in determining the correct dosage of the drug to obtain effective anticoagulation. Altough there are miscellaneous reasons for this variability a great emphasis is often incorrectly placed on food interaction. The article provides an overview of several possible causes of interindividual variability in warfarin dose and their clinical importance.

Immunosuppressive drugs in cardiology

doc.MUDr.Ivan Málek, CSc., MUDr.Markéta Hegarová

Interní Med. 2011; 13(11): 436-439  

The aim of the article is to provide a basic information about immunosuppressive drugs and their use in cardiology. The most frequent indication for immunosuppressants is the prevention and treatment of rejection after cardiac transplantation. Drugs with antiproliferative effect (m-TOR inhibitors) are also the most frequent ones used in drug-eluting coronary stents, decreasing significanty the rate of restenosis. Another form of coronary proliferative syndrome, chronic rejection after cardiac transplantation, can be effectively influenced with systemic aplication of these drugs. Another indication for immunosuppressives present some types of...

Low molecular weight heparins - their significance in current practice

prof.MUDr.Jan Bultas, CSc., doc.MUDr.Debora Karetová, CSc.

Interní Med. 2011; 13(11): 440-444  

With the advent of novel direct thrombin inhibitors (dabigatran) or factor Xa inhibitors (rivaroxaban, apixaban, etc.), a need has emerged to critically evaluate the role of established indirect factor Xa inhibitors and thrombin inhibitors, low molecular weight heparins (LMWHs), and to redefine their position among the other anticoagulants. Given the rapid onset of action, a reliable effect, the possibility to be administered once or twice daily and lower treatment costs, LMWHs remain to be effective drugs in the prophylaxis of thrombotic complications during procedures involving weight-bearing joints. For this indication, rivaroxaban and apixaban...

The man with secondary lymphoedema

MUDr.Veronika Flášarová

Interní Med. 2011; 13(11): 450-452  

The pacient with secondary lymphoedema and many cancer diseases localised in pelvis minor. The operations and radical radiotherapy came to damage lymphatic system and progress secondary lymphoedema. This disease was treated by compression and presotherapy and than the lymphoedema was reduced and the quality of patient’s life was improved.

Mycoses and antifungals

doc.MUDr.Petr Hamal, Ph.D., MDDr.Lucie Svobodová

Interní Med. 2011; 13(11): 445-449  

In the article, basic characteristics of mycoses and etiological agents’ specification are presented, with emphasis on infections frequently occurring in medical practice. Proper sampling is crucial for determination or verification of clinically suspected fungal infections. Guidelines for the collection of clinical specimen for mycological examination are described in detail. Further, an overview and brief characterization of diagnostic methods currently used in mycology laboratories are given and their limits in terms of speed and reliability are specified. Finally, a recent overview of registered antifungal drugs including their forms...

How to help patients stop smoking?

MUDr.Eva Králíková, CSc.

Interní Med. 2011; 13(11): 453-454  

Tobacco dependence is not easy to get rid of, nicotine is more addictive than heroin and psychosocial ties are also strong. Most smokers start with cigarettes in their childhood and adult regret – seven out of ten adult smokers would prefer not to smoke. Attempting without any assistance, however, tends to have success (= year of abstinence) reach about 3–5 %, a short intervention of a doctor or nurse about 8–10 %, and intensive treatment including pharmacotherapy 25–35 %. Generally, treatment involves intervention (according to time of the health care professional) and possibly pharmacotherapy. Intensive treatment is...

Wine in prevention of cardiovascular diseases and aging

prof.MUDr.Milan Šamánek, DrSc., doc.MUDr.Zuzana Urbanová, CSc.

Interní Med. 2011; 13(11): 455-456  

We have been drinking wine at least for 10 000 years or longer, in our region already from Celtic and Germanic times. Favorable effects on prevention of myocardial infarction, stroke, diabetes and hypertension were demonstrated recently, following attempts to use alcohol for treatment in ancient times. Favorable effects of wine drinking could be seen also in aging population. The best results for men are reached by daily drinking of 20–40 g alcohol at dinner. A moderate dose for women represents half of the dose for men.

Profesor Rybka, renesanční internista a zakladatel moderní české diabetologie, slaví 80

doc. MUDr. Alena Šmahelová, Ph.D.

Interní Med. 2011; 13(11): 457  

Autodidaktický test 10/2011

Interní Med. 2011; 13(11): 458